What Is The Safest Drug For Erectile Dysfunction

What Is The Safest Drug For Erectile Dysfunction?

Erectile dysfunction drugs with prescription are available for sale across leading drugstores as well as online pharmaceuticals and are generally safe for most of us. The presence of a clinically proven active component within the medicines makes it a reliable solution for the effective treatment of sexual conditions that limit men from experiencing the satisfactory sexual performance. However, there are indeed some contraindications of the medicines that have to be kept in mind, especially by those consuming some other drugs to treat their chronic or inherent medical condition.

Factors Causing Erectile Dysfunction

Erectile dysfunction can be a reason for smoking, excessive drinking, injuries, hormonal imbalances, and drug reactions and frequent encounters with erection failures can be managed by controlling these factors. However, if it becomes an ongoing issue. It can result in stress, affect self-confidence and add to relationship problems.

Moreover, erectile dysfunction can be indication of an underlying physiological or psychological condition. Also, there is a possibility of both of these conditions that worsens the case even more. Some physiological reasons can be obesity, high cholesterol, diabetes, and high blood pressure along with several psychological troubles comprising stress, depression, anxiety, fear, and low self-esteem that are known to intensify these sexual issues.

Drugs Available For Erectile Dysfunctitheiron

Medicinal safety is the most concerning topics in pharmacology, specifically with regard to introducing and approving new medication or questioning the efficacy and effects of a particular drug in the market. We usually prefer medications that have acquired some sort of safety recognition to ensure its quality.

In general, Erectile dysfunction medications available in the market are composed of some active ingredients that effectively relieve the sexual conditions. Components namely Sildenafil Citrate, Tadalafil, Vardenafil, and Avanafil are approved by the Food and Drug Administration (FDA) for treating the erectile dysfunction conditions.

These active components are extensively used to compose ED medications. Which serves as a remedial solution for men facing difficulties due to constant erection failures even after attaining a sexually aroused state. The medicine helps to instigate an abundant flow of blood in the penile region by overcoming arterial blockages that further help men to attain or maintain an erection for a prolonged duration during sexual intercourse. The component gets readily assimilated into the body and stays active in the bloodstream for an extended period.

Let Us Have A Look At The Active Components One By One

  • Sildenafil Citrate

It is most commonly known by the brand name Viagra, and is the most preferred treatment for erectile dysfunction. It has been prevalent and has established trust among the users as well as the healthcare professionals over the years. Its existence for a significant period has made the doctors confident while prescribing it as its side effects and interactions are very well-known.

Sildenafil Citrate composed medicines must be taken about half an hour before indulging in sexual activity, preferably on an empty stomach. It is better to avoid the consumption of large or fatty meals around the time of taking the medicine.

  • Cialis

Moreover, It works quite differently from the rest of the ED medicines. After its ingestion it doesn’t get readily assimilated as it stays in the body for longer comparatively. In addition, apart from treating ED. These medications are also prescribed for treating benign prostatic hyperplasia (BPH).

  • Vardenafil

Its brand name is Levitra. It should be taken only once a day, with or without food. It has to be ingested almost an hour before an anticipated sexual interaction.

  • Avanafil

Known by the brand name Stendra, its three doses: 50 mg, 100 mg, and 200 mg are FDA-approved. Doses can be altered according to the need and severity as advised by the doctor.

Mechanism Of Action Of Erectile Dysfunction Drugs

Each of these four components belongs to a group of Phosphodiesterase type-5 (PDE5) inhibitors that are responsible for stopping the secretion of the Phosphodiesterase type 5 (PDE5) enzymes. PDE5 enzymes are found in the smooth muscle cells of the walls of the blood vessels responsible for carrying blood to the penile tissues. PDE5 enzymes clog and narrow the blood vessels of the corpus cavernosum of the penile and in turn block the passages thereby affecting the proper flow to the penile organ.

Subsequently, the medicine successfully inhibits the release of PDE-5 enzymes which further triggers the discharge of a powerful substance known as Nitric oxide (NO). Which is one of the mediators of vasodilation. Nitric oxide (NO) releases the Guanylate cyclase (GC) 0enzyme that catalyzes the synthesis of cyclic Guanosine Monophosphate (cGMP) enzymes. In such a manner, ED medicine metabolizes the cGMP enzymes that relax the muscle blockages or strains by controlling the contraction, vasodilation, and regulation of proper blood in the penile shaft. And leads to a stronger erection suitable to be indulging in long-lasting sexual activity.

Safety Measures While Consuming Erectile Dysfunction Drugs

Apart from its incredible benefits in improving the sexual experience.

It might have some consequences in the mild category such as

  • nausea,
  • headaches,
  • flushing,
  • insomnia,
  • vomiting,
  • rashes,
  • sore throat,
  • nasal congestion,
  • stomach ache,
  • back pain, and blurred vision,
  • diarrhea, and dizziness.

These minor effects are common and tend to disappear after a brief time.

Additionally, interactions of these ED medications along with some nitrates-based drugs can lead to severe effects that can be life-threatening. Therefore, men with a medical history or an ongoing medical condition must inform their doctors about their condition before considering these ED medications.


The safest drug for treating erectile dysfunction is the one prescribed the medical professional. As professionals are experienced in taking all the factors in consideration before prescribing it to the patient. They may recommend an appropriate ED drug over another according to some factors relating to age, weight, allergies or medical history.

There are branded medicines available in the market that are popular among men. But that doesn’t necessarily mean one works better than the other or ensures its safety. Therefore, it is necessary to consult a medical professional that would help us in getting an appropriate medicine according to our needs and suitability.

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